Elacestrant

Generic name: elacestrant [ EL-a-KES-trant ]
Brand name: Orserdu
Dosage form: oral tablet (345 mg; 86 mg)
Drug classes: Estrogen receptor antagonists, Hormones / antineoplastics

Medically reviewed by Drugs.com on Oct 17, 2023. Written by Cerner Multum.

What is elacestrant?

Elacestrant is used to treat advanced hormone-related breast cancer in postmenopausal women and adult men when cancer has progressed or has spread to other parts of the body (metastatic) after other treatments have failed.

Your doctor will make sure you have the correct tumor type to be treated with elacestrant.

Elacestrant may also be used for purposes not listed in this medication guide.

Elacestrant side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Common side effects of elacestrant may include:

• muscle and joint pain;

• nausea, vomiting, loss of appetite;

• increased cholesterol and triglyceride levels in your blood;

• abnormal kidney or liver function tests.

• headache;

• diarrhea, constipation;

• feeling tired;

• stomach pain, heartburn;

• low blood sodium;

• hot flush; or

• low red blood cells (anemia).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Elacestrant can harm an unborn baby if the mother or the father is using elacestrant.

• If you are a woman, use birth control while using this medicine.

• If you are a man, use birth control if your sex partner is able to get pregnant.

Before taking this medicine

Tell your doctor if you have ever had:

• high cholesterol or triglycerides;

• liver disease.

Elacestrant can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 1 week after your last dose.

• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose.

• Tell your doctor right away if a pregnancy occurs.

Elacestrant may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

How should I take elacestrant?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take elacestrant once a day at the same time each day.

Take elacestrant with food.

Do not change your dose or stop taking elacestrant without your doctor's advice.

Swallow the tablet whole and do not crush, chew, or break it. Do not use a broken tablet.

If you vomit shortly after taking elacestrant, do not take another dose. Take your next dose as scheduled.

You will need frequent blood tests to check your cholesterol and triglycerides before and during treatment with elacestrant.

Store at room temperature away from moisture and heat.

Elacestrant dosing information

Usual Adult Dose for Breast Cancer:

345 mg orally once a day with food
Duration of therapy: Until disease progression or unacceptable toxicity

Use: For the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 6 hours late for the dose. Use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking elacestrant?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect elacestrant?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect elacestrant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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